CAS: 117-39-5



Other names:

Sophoretin; Meletin; Xanthaurine; Quercetine; Quercetol; Quercitin; Quertine; Flavin meletin

Quercetin, one of the main flavonoids that exists in galangal (Zingiberaceae), is a hydroxylated flavanoid that has been shown to cause potent reversible inhibition of fatty-acid synthase. It possesses potential antiinflammatory properties. Quercetin also inhibits Trk (tyrosine protein kinase), phospholipase A2, PDE (phosphodiesterases), mitochondrial ATPase, PI 3-kinase and PKC (protein kinase C). It has been reported that the competitive inhibition of FASN by quercetin leads to apoptotic cell death which results in inhibition of cell proliferation. Quercetin also behaves as a GPR30 activator and calcium channel protein inhibitor.



UniProt ID

Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: Cystic fibrosis transmembrane conductance regulator, Gene: CFTR
Protein: Solute carrier family 15 member 1, Gene: SLC15A1
Protein: Caspase-3, Gene: CASP3
Protein: Caspase-7, Gene: CASP7
Gene: MAP2K1
Protein: Dual specificity mitogen-activated protein kinase kinase 2, Gene: MAP2K2
Protein: Adenosine receptor A1, Gene: ADORA1
Protein: Putative uncharacterized protein ADORA2A-AS1, Gene: ADORA2A-AS1
Gene: ADORA3
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Monocarboxylate transporter 2, Gene: SLC16A7
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Protein: Aryl hydrocarbon receptor, Gene: AHR
Protein: Aldo-keto reductase family 1 member B10, Gene: AKR1B10
Protein: Aldose reductase, Gene: AKR1B1
Protein: Alcohol dehydrogenase [NADP(+)], Gene: AKR1A1
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Gene: CSNK2A1
Protein: Casein kinase II subunit alpha', Gene: CSNK2A2
Protein: Casein kinase II subunit beta, Gene: CSNK2B
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: Cyclin-dependent kinase 2, Gene: CDK2
Protein: Cyclin-dependent-like kinase 5, Gene: CDK5
Protein: Cyclin-dependent kinase 6, Gene: CDK6
Protein: C-type natriuretic peptide, Gene: NPPC
Protein: Catechol O-methyltransferase, Gene: COMT
Protein: Prostaglandin G/H synthase 2, Gene: PTGS2
Gene: CYP19A1
Protein: Cytochrome P450, Gene: CYP1A1
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Cytochrome P450 2B6, Gene: CYP2B6
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Protein: Cytochrome P450 2C19, Gene: CYP2C19
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: Cytochrome P450 2J2, Gene: CYP2J2
Protein: Glycogen synthase kinase-3 alpha, Gene: GSK3A
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: Estradiol 17-beta-dehydrogenase 1, Gene: HSD17B1
Protein: 3-keto-steroid reductase, Gene: HSD17B7
Protein: Inhibitor of nuclear factor kappa-B kinase subunit beta, Gene: IKBKB
Protein: Inositol polyphosphate multikinase, Gene: IPMK
Protein: Inositol-trisphosphate 3-kinase A, Gene: ITPKA
Protein: Inositol-trisphosphate 3-kinase B, Gene: ITPKB
Protein: Inositol-trisphosphate 3-kinase C, Gene: ITPKC
Protein: Arylamine N-acetyltransferase 1, Gene: NAT1
Protein: Arylamine N-acetyltransferase 2, Gene: NAT2
Protein: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Gene: PIK3CA
Gene: PIK3CB
Protein: Putative uncharacterized protein PIK3CD-AS1, Gene: PIK3CD-AS1
Protein: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, Gene: PIK3C2A
Gene: PIK3C2B
Gene: PIK3C2G
Protein: Phosphatidylinositol 4-kinase type 2-beta, Gene: PI4K2B
Protein: Phosphatidylinositol 4-kinase alpha, Gene: PI4KA
Protein: Phosphatidylinositol 4-kinase beta, Gene: PI4KB
Protein: Phosphatidylinositol 4-kinase type 2-alpha, Gene: PI4K2A
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
Protein: Serine/threonine-protein kinase PLK1, Gene: PLK1
Protein: Homeobox protein PKNOX1, Gene: PKNOX1
Protein: cGMP-dependent protein kinase 2, Gene: PRKG2
Protein: Tyrosine-protein phosphatase non-receptor type, Gene: PTPN1
Protein: Sulfotransferase 1A1, Gene: SULT1A1
Protein: Estrogen sulfotransferase, Gene: SULT1E1
Protein: Sulfotransferase, Gene: SULT2A1
Protein: DNA topoisomerase 2-alpha, Gene: TOP2A
Protein: DNA topoisomerase 2-beta, Gene: TOP2B
Protein: UDP-glucuronosyltransferase 1-3, Gene: UGT1A3
Protein: Potassium voltage-gated channel subfamily A member 5, Gene: KCNA5
Protein: Monocarboxylate transporter 1, Gene: SLC16A1
Protein: Solute carrier organic anion transporter family member 2B1, Gene: SLCO2B1
Gene: SLCO1B1
Protein: Serine/threonine-protein kinase Chk1, Gene: CHEK1
Gene: DGAT1
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: Ribosyldihydronicotinamide dehydrogenase [quinone], Gene: NQO2
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Serine/threonine-protein kinase Sgk1, Gene: SGK1


oral LD50 [mouse] mg/kg
> 159.0
oral LD50 [rat] mg/kg
> 161.0
oral LD50 [rabbit] mg/kg

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Diabetic






Longevity mechanisms activation


Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts; Reduce the risk of cataract formation

20619334 21978083

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

200 mkM

More info about experiment

Opposite effectNo