Nitroflurbiprofen

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CAS: 158836-71-6

Name:

Nitroflurbiprofen

Other names:

Flurbinitroxybutylester; Nitroxybutyl flurbiprofen; 4-(Nitrooxy)butyl 2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetate

An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins [ChEBI].

Interactions

Description

UniProt ID

Protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma, Gene: FAM120B
Protein: Prostaglandin G/H synthase 2, Gene: PTGS2

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

PTGS2

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
12.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

200 mg/kg of food

More info about experiment

18631321
Opposite effectNo