Minocycline
CAS: 10118-90-8
Name:
Minocycline
Other names:
Minocyclin; Minociclina; Minocyclinum; Minocin; Dynacin; Aknemin; Apo-Minocycline; Minocyclinum [INN-Latin]; Arestin
A tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. [PubChem]
Interactions
Description
UniProt ID
Protein: ADP/ATP translocase 1, Gene: SLC25A4
Gene: SLC25A5
Gene: SLC25A6
Protein: Cytochrome c, Gene: CYCS
Protein: Matrix metalloproteinase-9, Gene: MMP9
Protein: Solute carrier family 22 member 6, Gene: SLC22A6
Gene: SLC22A7
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 2380.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Depressant
Neuroprotective
Cardioprotective
Antibacterial
S4226
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to aging associated genes
No data available
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 29.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo
Model organism
ModelDrosophila melanogaster
SrainOregon-R-C
SexMale
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 46.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,05 mM
More info about experiment
Opposite effectNo