Ibuprofen
CAS: 15687-27-1
Name:
Ibuprofen
Other names:
Motrin; Brufen; Dolgit; Liptan; Nuprin
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) derivative of propionic acid used for relieving pain, helping with fever and reducing inflammation. About 60% of people improve with any given NSAID and it is recommended that if one does not work that another should be tried. Ibuprofen might be considered a weaker anti-inflammatory than other NSAIDs [Wikipedia]
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- > 740.0
- oral LD50 [rat] mg/kg
- > 636.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Cardiovascular risks associated with low-dose ibuprofen and diclofenac
Relation to aging associated genes
No data available
Model organism
ModelSaccharomyces cerevisiae
SrainBY4742
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- 17.0
Concentration wth maximum effect
0.2 mM
More info about experiment
Opposite effectNo
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Agar nematode growth medium + UV killed E. coli OP50Life Extension
- Mean LS (%)
- —
- Median LS (%)
- 10.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0.1 mM
More info about experiment
Opposite effectNo
Model organism
ModelDrosophila melanogaster
SrainCanton-S
SexMale
Age of treatment—
Experimental conditions
agar/semolina/sugar/yeast mediumLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 10.0
- Mortality rate derease (%)
- —
- Max LS (%)
- 0.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0.05 µM
More info about experiment
Opposite effectNo
Model organism
ModelDrosophila melanogaster
SrainCanton-S
SexFemale
Age of treatment—
Experimental conditions
agar/semolina/sugar/yeast mediumLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 10.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0.05 µM
More info about experiment
Opposite effectNo