Enalapril

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CAS: 75847-73-3

Name:

Enalapril

Other names:

Vasotec; Enalaprilum; CHEBI:4784; Acetensil; Amprace; Feliberal; NCGC00021569-04; DSSTox_CID_2982; DSSTox_RID_76817

Enalapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalaprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Obesity
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Calorie Restriction Mimetics

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Treatment of elderly hypertensive

17581601

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
40.0
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mg/kg/day

More info about experiment

19549507
Opposite effectNo