DAPH
CAS: 145915-58-8
Name:
DAPH
Other names:
4,5-dianilinophthalimide; Cgp 52411; 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione; 5,6-dianilino-1h-isoindole-1,3(2h)-dione
DAPH is a tyrosine kinase inhibitor, which suppresses and reverses the formation of Aβ42 fibers in neurons. DAPH displays specificity towards the EGFR kinase3 receptor. Studies suggest that DAPH can attenuate phenylephrine-induced endothelium contraction in aortic rings. It is known that Aβ42 proteins are composed of β sheets that are arranged parallel to the fibril axis and are several micrometers in length. DAPH is a useful tool in inhibiting these proteins because it can disrupt fibril formation which is vital for β sheet formation.
Interactions
Description
UniProt ID
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Amiloid
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
+
Suppression of aging mechanisms
No dataRelation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 15.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo