Danazol
CAS: 17230-88-5
Name:
Danazol
Other names:
Danocrine; Cyclomen; Danol; Chronogyn; Ladogal; Winobanin; anatrol; Danatrol; Danazolum
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. [PubChem]
Interactions
Description
UniProt ID
Gene: CYP19A1
Protein: Amphiregulin, Gene: AREGAREGB
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: Cytochrome P450 2J2, Gene: CYP2J2
Protein: Dihydroorotate dehydrogenase (quinone), mitochondrial, Gene: DHODH
Protein: Ubiquitin-associated and SH3 domain-containing protein B, Gene: UBASH3B
Protein: Sulfotransferase, Gene: SULT2A1
Protein: Bile salt export pump, Gene: ABCB11
Toxicity
- oral LD50 [mouse] mg/kg
- > 4830.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 13.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo