D-Glucosamine

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CAS: 3416-24-8

Name:

D-Glucosamine

Other names:

chitosamine; 2-Amino-2-deoxy-D-glucose; STK801823; (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol

Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
> 15000.0
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Prevent and treat osteoarthritis in humans

15621331 10732937 11214126

Relation to aging associated genes

No data available

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
8.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
8.0
Cell CLS
Cell RLS

Concentration wth maximum effect

100 μM

More info about experiment

24714520
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

10 g/kg in the diet

More info about experiment

24714520
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
18.0
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

More info about experiment

22828954
Opposite effectNo