Cyclosporin A

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CAS: 59865-13-3

Name:

Cyclosporin A

Other names:

Ciclosporin; Cyclosporin; Sigmasporin; Cyclokat; Mitogard; Papilock; Pulminiq; Vekacia

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).

Interactions

Description

UniProt ID

Gene: SLCO1B1
Protein: Solute carrier organic anion transporter family member 1B3, Gene: SLCO1B3
Protein: ATP-binding cassette sub-family B member 5, Gene: ABCB5
Protein: Multidrug resistance-associated protein 7, Gene: ABCC10
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, Gene: PPP3CA
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, Gene: PPP3CB
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, Gene: PPP3CC
Protein: Calcineurin subunit B type 1, Gene: PPP3R1
Protein: Calcineurin subunit B type 2, Gene: PPP3R2
Protein: Peptidyl-prolyl cis-trans isomerase A, Gene: PPIA
Protein: Peptidyl-prolyl cis-trans isomerase B, Gene: PPIB
Protein: Peptidyl-prolyl cis-trans isomerase C, Gene: PPIC
Protein: Peptidyl-prolyl cis-trans isomerase E, Gene: PPIE
Gene: PPIG
Protein: Peptidyl-prolyl cis-trans isomerase, Gene: PPIH
Gene: CYP3A4
Protein: Multidrug resistance protein 1, Gene: ABCB1
Protein: Multidrug resistance protein 3, Gene: ABCB4
Protein: Nuclear factor of activated T-cells, cytoplasmic 1, Gene: NFATC1
Protein: Nuclear factor of activated T-cells, cytoplasmic 3, Gene: NFATC3
Protein: NK-tumor recognition protein, Gene: NKTR
Protein: Peptidyl-prolyl cis-trans isomerase D, Gene: PPID
Protein: Peptidyl-prolyl cis-trans isomerase F, mitochondrial, Gene: PPIF
Protein: Peptidyl-prolyl cis-trans isomerase-like 1, Gene: PPIL1
Protein: Probable ATP-dependent RNA helicase YTHDC2, Gene: YTHDC2
Protein: fMet-Leu-Phe receptor, Gene: FPR1
Protein: Sodium/bile acid cotransporter, Gene: SLC10A1
Protein: Solute carrier organic anion transporter family member 4C1, Gene: SLCO4C1
Gene: Abcb1b
Protein: Multidrug resistance-associated protein 1, Gene: ABCC1
Protein: ATP-binding cassette sub-family G member 1, Gene: ABCG1
Protein: Bile salt export pump, Gene: ABCB11
Protein: Mineralocorticoid receptor, Gene: NR3C2
Protein: Interleukin enhancer-binding factor 2, Gene: ILF2
Protein: Interleukin enhancer-binding factor 3, Gene: ILF3

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 1480.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Obesity
Neuroprotective
Antibacterial

No

Antifungal

24722799.0

Antiviral

No

Longevity mechanisms activation

Hormetin
+
Stress Resistance

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Stimulatory effects of cyclosporin A on human and mouse thymic epithelial cells

3556386

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
15.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo