Warning! Toxic compound!

Baicalein

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CAS: 491-67-8

Name:

Baicalein

Other names:

5,6,7-Trihydroxyflavone; Biacalein; 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one; NSC661431; NSC 661431

Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) and 12-LO (12-lipoxygenases) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.

Interactions

Description

UniProt ID

Protein: Aryl hydrocarbon receptor, Gene: AHR
Protein: Aldo-keto reductase family 1 member B10, Gene: AKR1B10
Protein: Aldose reductase, Gene: AKR1B1
Protein: Arachidonate 12-lipoxygenase, 12S-type, Gene: ALOX12
Protein: Arachidonate 15-lipoxygenase, Gene: ALOX15
Protein: Arachidonate 15-lipoxygenase B, Gene: ALOX15B
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Gene: CYP19A1
Gene: CYP3A4
Protein: E-selectin, Gene: SELE
Protein: Gamma-aminobutyric acid receptor subunit alpha-1, Gene: GABRA1
Protein: Gamma-aminobutyric acid receptor subunit alpha-4, Gene: GABRA4
Protein: Gamma-aminobutyric acid receptor subunit alpha-3, Gene: GABRA3
Protein: Gamma-aminobutyric acid receptor subunit alpha-5, Gene: GABRA5
Protein: Gamma-aminobutyric acid receptor subunit alpha-6, Gene: GABRA6
Protein: Testosterone 17-beta-dehydrogenase 3, Gene: HSD17B3
Protein: 5-hydroxytryptamine receptor 7, Gene: HTR7
Protein: L-selectin, Gene: SELL
Gene: SELP
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
Protein: Citrate synthase, mitochondrial, Gene: CS
Protein: Transthyretin, Gene: TTR
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Gene: RELA

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Anti-inflammatory effects; Inhibition the growth of human lung squamous carcinoma CH27 cells

18039391 15868934

Relation to aging associated genes

TERTLRP2

Experimental conditions

Not available

Life Extension

Mean LS (%)
45.0
Median LS (%)
57.0
Mortality rate derease (%)
Max LS (%)
24.0
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mkM

More info about experiment

23339711
Opposite effectNo

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
52.0
Cell CLS
Cell RLS

Concentration wth maximum effect

0,1%

More info about experiment

22114686
Opposite effectNo