(R,R)-Cis-Diethyl Tetrahydro-2,8-Chrysenediol
CAS: 221368-54-3
Name:
(R,R)-Cis-Diethyl Tetrahydro-2,8-Chrysenediol
Other names:
R,R-THC; (R,R)-cis-Diethyl tetrahydro-2,8-chrysenediol; (R,R)-cis-Diethyltetrahydro-2,8-chrysenediol
(R,R)-THC is a non-steroidal, potent, and selective estrogen receptor (ER) ligand; agonist at ERα and antagonist at ERβ receptor.
Interactions
Description
UniProt ID
Protein: Estrogen receptor, Gene: ESR1
Protein: Estrogen receptor beta, Gene: ESR2
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
ESR1Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 7.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo